Biochemistry

obowiązkowe

Knowledge of the basic natural compounds, their structure, and their significance in the processes occurring in living organisms.

mieszany: w sali i zdalnie

Upon completion of this course, the student should understand the mechanisms of action and regulation of proteins and enzymes, be familiar with the basic metabolic processes and their regulatory mechanisms, as well as the processes of genetic information expression.

Structure of nucleic acids and their properties. Organization of the eukaryotic genome. DNA replication. Mechanism of transcription. Protein biosynthesis (translation). Protein targeting. Regulation of gene expression. Primary, secondary, tertiary and quaternary structure of proteins. Motifs and domains. Relationship between the structure and function of proteins using hemoglobin and myoglobin as examples. Formation of fibrous structures. Post-translational modifications of proteins. Catalysis and free energy. Structure of enzymes. Mechanism of enzymatic catalysis. Kinetics of enzymatic reactions. Regulation of enzymatic activity. Basic concepts of metabolism. High-energy compounds, phosphoryl transfer potential. Coenzymes involved in oxidation and reduction processes as well as in group transfer. Digestion of food components. Glycolysis and its regulation. Metabolism under anaerobic conditions (fermentations). Citric acid cycle and its regulation and significance. Structure and mechanism of the respiratory chain. Mechanism of oxidative phosphorylation. Energy balances of oxidation of various compounds. Gluconeogenesis. Glycogenolysis and glycogenesis. Pentose phosphate pathway. Beta-oxidation of fatty acids. Amino acid metabolism.

Estimated student workload during the semester – 50 hours total, including:

• participation in classes – 30 hours

• consultations – 5 hours

• preparation for the exam – 15 hours

J.M. Berg, J.L. Tymoczko, L. Stryer, Biochemistry

L. Stryer, Biochemistry

H.R. Matthews, R.A. Freedland, R.L. Miesfeld, Biochemistry and Molecular Biology: An Outline

Understands the role and position of chemistry within the structure of natural and exact sciences, as well as its contribution to the development of human civilization.

Knows the classification of organic compounds into classes corresponding to functional groups (nomenclature, structure, chemical reactions, methods of synthesis, occurrence, and applications).

Is familiar with the basics of biochemistry and understands the significance of chemical phenomena in processes occurring in living nature.

Knows and understands the fundamentals of physical chemistry, particularly chemical kinetics, including catalytic phenomena.

Possesses organized knowledge of ethical principles and standards related to scientific and educational activities.

Is aware of the scope of their own knowledge and skills and understands the need for continuous professional and personal development.

According to the Study Regulations at the University of Warsaw, attendance at classes is mandatory. The allowed number of absences from lectures is 3.

The course assessment consists of a written test exam an oral presentation on an assigned topic at the end of the course

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