Natural Compounds and Their Impact on Drug Synthesis

biologia
biotechnologia
chemia

fakultatywne
monograficzne

Basic knowledge of organic compounds chemistry.

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Acquisition of knowledge about natural biologically active compounds and their influence on the development of drug syntheses.

The lecture topics are the following: a review on main groups of secondary metabolites with distinguished biological activity (glycosides, alkaloids, steroids, terpenes, antibiotics): the most important plant raw materials; modern methods of increasing of selected metabolites content in plant material; alkaloids with strong activity toward nervous system as lead compounds in the search for counterpain drugs; natural substances exhibiting antineoplastic, mutagenic and carcinogenic activity and their influence on advances of chemotherapy; natural anticancer drugs of plant origin; drug acting on the nervous system and their non-medical application.

Estimated student workload per semester: 37.5 hours, including:

• 15 hours of class participation

• 7.5 hours of consultations

• 15 hours of exam preparation

1. Zejc Alfred, Gorczyca Maria "Chemia leków", Wydawnictwo Lekarskie PZWL, 2009

2. Silverman Richard "Chemia organiczna w projektowaniu leków", WNT, 2004

3. Patrick G."Chemia leków. Krótkie wykłady.", PWN, 2009

4. A. Kołodziejczyk „Naturalne związki organiczne", PWN, Warszawa 2006

KNOWLEDGE: After completing the course, the student knows and understands

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• has extensive knowledge of the place of chemistry in the system of exact and natural sciences and its importance for the development of humanity;

• has in-depth knowledge and skills in the selected chemical specialization, allowing them to use the methods and concepts appropriate for this specialization and enabling independent research;

• has advanced knowledge and skills in computational methods appropriate for a given chemical specialization;

• has a good understanding of current trends in chemistry and the latest scientific discoveries in a given chemical specialization;

• in particular:

• knows and understands the general principles governing the search for and synthesis of new medicinal substances;

SKILLS: After completing the course, the student is able to

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• possess advanced knowledge and skills enabling the use of professional literature, databases, and other sources of information, and to assess the reliability of the information obtained;

• be able to discuss the place of chemistry in the system of exact and natural sciences and its importance for the development of our civilization;

• explain, using selected examples, the importance of natural compounds in drug synthesis.

SOCIAL COMPETENCES: After completing the course, the student is ready for

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• continuous learning and independent search for information in literature, including foreign languages.

Final and retake exam in writing or credit work agreed with the lecturer.

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