Natural Compounds and Their Impact on Drug Synthesis

biologia
biotechnologia
chemia

fakultatywne
monograficzne

Basic knowledge of organic compounds chemistry.

w sali

Acquisition of knowledge about natural biologically active compounds and their influence on the development of drug syntheses.

The lecture topics are the following: a review on main groups of secondary metabolites with distinguished biological activity (glycosides, alkaloids, steroids, terpenes, antibiotics): the most important plant raw materials; modern methods of increasing of selected metabolites content in plant material; alkaloids with strong activity toward nervous system as lead compounds in the search for counterpain drugs; natural substances exhibiting antineoplastic, mutagenic and carcinogenic activity and their influence on advances of chemotherapy; natural anticancer drugs of plant origin; drug acting on the nervous system and their non-medical application.

1. Zejc Alfred, Gorczyca Maria "Chemia leków", Wydawnictwo Lekarskie PZWL, 2009

2. Silverman Richard "Chemia organiczna w projektowaniu leków", WNT, 2004

3. Patrick G."Chemia leków. Krótkie wykłady.", PWN, 2009

4. A. Kołodziejczyk „Naturalne związki organiczne", PWN, Warszawa 2006

After completing the lecture, a student should be able to explain the significance of natural compounds for the drug’s synthesis and give examples. Student should be able to understand major rules for seeking and synthesis of new drugs.

Final and retake exam in writing or credit work agreed with the lecturer.

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